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Fluconazole is indicated in adults for the prophylaxis of:

  • Relapse of cryptococcal meningitis in patients with high risk of recurrence.
  • Relapse of oropharyngeal or esophageal candidiasis in patients infected with HIV who are at high risk of experiencing relapse.
  • To reduce the incidence of recurrent vaginal candidiasis (4 or more episodes a year).
  • Prophylaxis of candida infections in patients with prolonged neutropenia (such as patients with hematological malignancies receiving chemotherapy or patients receiving Hematopoietic Stem Cell Transplantation.


Fluconazole is indicated in term newborn infants, infants, toddlers, children, and adolescents aged from 0 to 17 years old:

Fluconazole is used for the treatment of mucosal candidiasis (oropharyngeal, esophageal), invasive candidiasis, cryptococcal meningitis and the prophylaxis of candida infections in immunocompromised patients. Fluconazole can be used as maintenance therapy to prevent relapse of cryptococcal meningitis in children with high risk of reoccurrence.

Therapy may be instituted before the results of the cultures and other laboratory studies are known; however, once these results become available, anti-infective therapy should be adjusted accordingly.
Consideration should be given to official guidance on the appropriate use of antifungals.

Dosage and Administration

The dose should be based on the nature and severity of the fungal infection. Treatment of infections requiring multiple dosing should be continued until clinical parameters or laboratory tests indicate that active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection.